Nociceptive Sensitization Reduces Predation Risk
نویسندگان
چکیده
منابع مشابه
Nociceptive Sensitization Reduces Predation Risk
Sublethal injury triggers long-lasting sensitization of defensive responses in most species examined, suggesting the involvement of powerful evolutionary selection pressures [1]. In humans, this persistent nociceptive sensitization is often accompanied by heightened sensations of pain and anxiety [2]. While experimental [3] and clinical [4] evidence support the adaptive value of immediate nocic...
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BACKGROUND Nociceptive sensitization is a tissue damage response whereby sensory neurons near damaged tissue enhance their responsiveness to external stimuli. This sensitization manifests as allodynia (aversive withdrawal to previously nonnoxious stimuli) and/or hyperalgesia (exaggerated responsiveness to noxious stimuli). Although some factors mediating nociceptive sensitization are known, ina...
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DNA methylation is a key epigenetic mechanism controlling DNA accessibility and gene expression. Blockade of DNA methylation can significantly affect pain behaviors implicated in neuropathic and inflammatory pain. However, the role of DNA methylation with regard to postoperative pain has not yet been explored. In this study we sought to investigate the role of DNA methylation in modulating inci...
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BACKGROUND Heightened nociceptive (pain) sensitivity is an adaptive response to tissue damage and serves to protect the site of injury. Multiple mediators of nociceptive sensitization have been identified in vertebrates, but the complexity of the vertebrate nervous system and tissue-repair responses has hindered identification of the precise roles of these factors. RESULTS Here we establish a...
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I n the months leading up to the 1973 Yom Kippur War, the Egyptian military staged 40 maneuvers on or near the Israeli border. Over time, the Israelis learned that Egyptian activity near the border was not necessarily a threat to respond to, and they ultimately let their guard down, only to be surprised one day when the tanks and troops crossed the border as part of a coordinated invasion (1, 2...
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ژورنال
عنوان ژورنال: Current Biology
سال: 2014
ISSN: 0960-9822
DOI: 10.1016/j.cub.2014.03.043